The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis
AM Parfitt - Metabolic Bone Disease and Related Research, 1982 - Elsevier
The approximate equality of whole-body rates of formation and resorption over a wide
range, a phenomenon frequently but inaccurately referred to as coupling, depends on the
prompt and approximately complete refilling of each new resorption cavity with new bone.
This focal regulation of bone balance requires an adequate supply of new osteoblasts at the
right place at the right time, a process which presumably depends both on the availability of
precursor cells and on some form of coupling signal. It also requires that each new …
range, a phenomenon frequently but inaccurately referred to as coupling, depends on the
prompt and approximately complete refilling of each new resorption cavity with new bone.
This focal regulation of bone balance requires an adequate supply of new osteoblasts at the
right place at the right time, a process which presumably depends both on the availability of
precursor cells and on some form of coupling signal. It also requires that each new …