[HTML][HTML] IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner
M Maleszewska, JRAJ Moonen, N Huijkman… - Immunobiology, 2013 - Elsevier
Endothelial to mesenchymal transition (EndMT) contributes to fibrotic diseases. The main
inducer of EndMT is TGFβ signaling. TGFβ2 is the dominant isoform in the physiological
embryonic EndMT, but its role in the pathological EndMT in the context of inflammatory co-
stimulation is not known. The aim of this study was to investigate TGFβ2-induced EndMT in
the context of inflammatory IL-1β signaling. Co-stimulation with IL-1β and TGFβ2, but not
TGFβ1, caused synergistic induction of EndMT. Also, TGFβ2 was the only TGFβ isoform that …
inducer of EndMT is TGFβ signaling. TGFβ2 is the dominant isoform in the physiological
embryonic EndMT, but its role in the pathological EndMT in the context of inflammatory co-
stimulation is not known. The aim of this study was to investigate TGFβ2-induced EndMT in
the context of inflammatory IL-1β signaling. Co-stimulation with IL-1β and TGFβ2, but not
TGFβ1, caused synergistic induction of EndMT. Also, TGFβ2 was the only TGFβ isoform that …