The cytotoxic agent bleomycin is feared for its induction of sometimes fatal pulmonary
toxicity, also known as bleomycin-induced pneumonitis (BIP). The central event in the
development of BIP is endothelial damage of the lung vasculature due to bleomycin-induced
cytokines and free radicals. Ultimately, BIP can progress in lung fibrosis. The diagnosis is
established by a combination of clinical symptoms, radiographic alterations, and pulmonary
function test results, while other disorders resembling BIP have to be excluded. Pulmonary …