Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine

PS Frenette, S Pinho, D Lucas… - Annual review of …, 2013 - annualreviews.org
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs
themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs).
The ease by which human MSC-like and stromal progenitor cells can be isolated from the
bone marrow and other tissues has led to the rapid development of clinical investigations
exploring their anti-inflammatory properties, tissue preservation capabilities, and …