Involvement of the fibrogenic cytokines, TGF-β and bFGF, in the pathogenesis of idiopathic myelofibrosis
MC Le Bousse-Kerdiles, MC Martyre - Pathologie Biologie, 2001 - Elsevier
Idiopathic Myelofibrosis (IMF), is a chronic myeloproliferative disorder characterized by the
association of myeloproliferation and myelofibrosis. The pathophysiological mechanisms
resulting in this disease remain still unclear. The myeloproliferation appeared to result from
the clonal amplification of hematopoietic progenitors. In contrast, fibroblasts participating in
myelofibrosis were shown to be polyclonal, thus suggesting that myelofibrosis was a
reactive process. We studied the role of two growth factors TGF-β and bFGF, which display …
association of myeloproliferation and myelofibrosis. The pathophysiological mechanisms
resulting in this disease remain still unclear. The myeloproliferation appeared to result from
the clonal amplification of hematopoietic progenitors. In contrast, fibroblasts participating in
myelofibrosis were shown to be polyclonal, thus suggesting that myelofibrosis was a
reactive process. We studied the role of two growth factors TGF-β and bFGF, which display …