Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
AJ Bruce-Keller, JM Salbaum, M Luo, E Blanchard IV… - Biological …, 2015 - Elsevier
Background The prevalence of mental illness, particularly depression and dementia, is
increased by obesity. Here, we test the hypothesis that obesity-associated changes in gut
microbiota are intrinsically able to impair neurocognitive behavior in mice. Methods
Conventionally housed, nonobese, adult male C57BL/6 mice maintained on a normal chow
diet were subjected to a microbiome depletion/transplantation paradigm using microbiota
isolated from donors on either a high-fat diet (HFD) or control diet. Following re-colonization …
increased by obesity. Here, we test the hypothesis that obesity-associated changes in gut
microbiota are intrinsically able to impair neurocognitive behavior in mice. Methods
Conventionally housed, nonobese, adult male C57BL/6 mice maintained on a normal chow
diet were subjected to a microbiome depletion/transplantation paradigm using microbiota
isolated from donors on either a high-fat diet (HFD) or control diet. Following re-colonization …