[HTML][HTML] Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice
SE Jang, SM Lim, JJ Jeong, HM Jang, HJ Lee… - Mucosal …, 2018 - Elsevier
In this study, we tested our hypothesis regarding mechanistic cross-talk between
gastrointestinal inflammation and memory loss in a mouse model. Intrarectal injection of the
colitis inducer 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) in mice caused colitis via
activation of nuclear factor (NF)-κB and increase in membrane permeability. TNBS treatment
increased fecal and blood levels of lipopolysaccharide (LPS) and the number of
Enterobacteriaceae, particularly Escherichia coli (EC), in the gut microbiota composition, but …
gastrointestinal inflammation and memory loss in a mouse model. Intrarectal injection of the
colitis inducer 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) in mice caused colitis via
activation of nuclear factor (NF)-κB and increase in membrane permeability. TNBS treatment
increased fecal and blood levels of lipopolysaccharide (LPS) and the number of
Enterobacteriaceae, particularly Escherichia coli (EC), in the gut microbiota composition, but …