Large-scale field trial of Ty21a live oral typhoid vaccine in enteric-coated capsule formulation
MM Levine, RE Black, C Ferreccio, R Germanier… - The Lancet, 1987 - Elsevier
MM Levine, RE Black, C Ferreccio, R Germanier, CT Committee
The Lancet, 1987•ElsevierThree doses, given within one week, of Ty21a attenuated Salmonella typhi oral vaccine in
an enteric-coated formulation provided 67% efficacy for at least 3 years in a randomised,
placebo-controlled field trial involving 109 000 schoolchildren in Santiago, Chile. Increasing
the interval between doses to twenty-one days did not enhance protection. Significantly less
protection followed administration of vaccine in gelatin capsules with sodium bicarbonate.
Ty21a provides the same level of protection as the heat/phenol-inactivated whole cell …
an enteric-coated formulation provided 67% efficacy for at least 3 years in a randomised,
placebo-controlled field trial involving 109 000 schoolchildren in Santiago, Chile. Increasing
the interval between doses to twenty-one days did not enhance protection. Significantly less
protection followed administration of vaccine in gelatin capsules with sodium bicarbonate.
Ty21a provides the same level of protection as the heat/phenol-inactivated whole cell …
Abstract
Three doses, given within one week, of Ty21a attenuated Salmonella typhi oral vaccine in an enteric-coated formulation provided 67% efficacy for at least 3 years in a randomised, placebo-controlled field trial involving 109 000 schoolchildren in Santiago, Chile. Increasing the interval between doses to twenty-one days did not enhance protection. Significantly less protection followed administration of vaccine in gelatin capsules with sodium bicarbonate. Ty21a provides the same level of protection as the heat/phenol-inactivated whole cell parenteral vaccine but differs in not causing adverse reactions. Ty21a may now be regarded as a practical public health tool.
Elsevier