[HTML][HTML] Unmanipulated HLA 2-3 antigen–mismatched (haploidentical) bone marrow transplantation using only pharmacological GVHD prophylaxis
H Ogawa, K Ikegame, K Kaida, S Yoshihara… - Experimental …, 2008 - Elsevier
OBJECTIVE: The incidence of severe graft-vs-host disease (GVHD) in unmanipulated
human leukocyte antigen (HLA) 2-3 antigen–mismatched bone marrow transplantation
(BMT) using cyclosporine and methotrexate as GVHD prophylaxis is 80% to 90%. We
investigated whether pharmacological GVHD prophylaxis consisting of four drugs, including
a steroid, effectively suppressed GVHD in this transplantation setting. MATERIALS AND
METHODS: Thirty patients who had hematologic malignancies at an advanced stage or with …
human leukocyte antigen (HLA) 2-3 antigen–mismatched bone marrow transplantation
(BMT) using cyclosporine and methotrexate as GVHD prophylaxis is 80% to 90%. We
investigated whether pharmacological GVHD prophylaxis consisting of four drugs, including
a steroid, effectively suppressed GVHD in this transplantation setting. MATERIALS AND
METHODS: Thirty patients who had hematologic malignancies at an advanced stage or with …
