Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity
Y Li, S Shaw, EJ Kamsteeg, A Vandewalle… - Journal of the …, 2006 - journals.lww.com
In antidiuresis, vasopressin (AVP) occupation of V2 receptors in renal collecting ducts
activates adenylyl cyclase, resulting in increased intracellular cAMP levels, which activates
protein kinase A (PKA). PKA phosphorylates both the cAMP responsive element binding
protein, which induces aquaporin-2 (AQP2) transcription, and AQP2, which then is
translocated to the apical membrane, allowing urine concentration. Lithium treatment often
causes nephrogenic diabetes insipidus (NDI), which coincides with decreased AQP2 …
activates adenylyl cyclase, resulting in increased intracellular cAMP levels, which activates
protein kinase A (PKA). PKA phosphorylates both the cAMP responsive element binding
protein, which induces aquaporin-2 (AQP2) transcription, and AQP2, which then is
translocated to the apical membrane, allowing urine concentration. Lithium treatment often
causes nephrogenic diabetes insipidus (NDI), which coincides with decreased AQP2 …