Lithium causes G2 arrest of renal principal cells
T de Groot, M Alsady, M Jaklofsky… - Journal of the …, 2014 - journals.lww.com
Vasopressin-regulated expression and insertion of aquaporin-2 channels in the luminal
membrane of renal principal cells is essential for urine concentration. Lithium affects urine
concentrating ability, and approximately 20% of patients treated with lithium develop
nephrogenic diabetes insipidus (NDI), a disorder characterized by polyuria and polydipsia.
Lithium-induced NDI is caused by aquaporin-2 downregulation and a reduced ratio of
principal/intercalated cells, yet lithium induces principal cell proliferation. Here, we studied …
membrane of renal principal cells is essential for urine concentration. Lithium affects urine
concentrating ability, and approximately 20% of patients treated with lithium develop
nephrogenic diabetes insipidus (NDI), a disorder characterized by polyuria and polydipsia.
Lithium-induced NDI is caused by aquaporin-2 downregulation and a reduced ratio of
principal/intercalated cells, yet lithium induces principal cell proliferation. Here, we studied …