Adenylyl cyclases in the digestive system
Cellular signalling, 2014•Elsevier
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very
diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its
own pattern of expression in the digestive system and differential regulation of function by
Ca 2+ and other intracellular signals. In addition to the transmembrane isoforms, one AC is
soluble and exhibits distinct regulation. In this review, the basic structure, regulation and
physiological roles of ACs in the digestive system are discussed.
diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its
own pattern of expression in the digestive system and differential regulation of function by
Ca 2+ and other intracellular signals. In addition to the transmembrane isoforms, one AC is
soluble and exhibits distinct regulation. In this review, the basic structure, regulation and
physiological roles of ACs in the digestive system are discussed.
Abstract
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca2 + and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
Elsevier