Renal phosphate wasting in the absence of adenylyl cyclase 6
RA Fenton, F Murray, JAD Rieg, T Tang… - Journal of the …, 2014 - journals.lww.com
Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) enhance phosphate
excretion by the proximal tubule of the kidney by retrieval of the sodium-dependent
phosphate transporters (Npt2a and Npt2c) from the apical plasma membrane. PTH activates
adenylyl cyclase (AC) through PTH 1 receptors and stimulates the cAMP/PKA signaling
pathway. However, the precise role and isoform (s) of AC in phosphate homeostasis are not
known. We report here that mice lacking AC6 (AC6−/−) have increased plasma PTH and …
excretion by the proximal tubule of the kidney by retrieval of the sodium-dependent
phosphate transporters (Npt2a and Npt2c) from the apical plasma membrane. PTH activates
adenylyl cyclase (AC) through PTH 1 receptors and stimulates the cAMP/PKA signaling
pathway. However, the precise role and isoform (s) of AC in phosphate homeostasis are not
known. We report here that mice lacking AC6 (AC6−/−) have increased plasma PTH and …