Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla
T Rieg, T Tang, F Murray, J Schroth… - Journal of the …, 2010 - journals.lww.com
Arginine vasopressin (AVP) enhances water reabsorption in the renal collecting duct by
vasopressin V 2 receptor (V 2 R)-mediated activation of adenylyl cyclase (AC), cAMP-
promoted phosphorylation of aquaporin-2 (AQP2), and increased abundance of AQP2 on
the apical membrane. Multiple isoforms of adenylate cyclase exist, and the roles of
individual AC isoforms in water homeostasis are not well understood. Here, we found that
levels of AC6 mRNA, the most highly expressed AC isoform in the inner medulla, inversely …
vasopressin V 2 receptor (V 2 R)-mediated activation of adenylyl cyclase (AC), cAMP-
promoted phosphorylation of aquaporin-2 (AQP2), and increased abundance of AQP2 on
the apical membrane. Multiple isoforms of adenylate cyclase exist, and the roles of
individual AC isoforms in water homeostasis are not well understood. Here, we found that
levels of AC6 mRNA, the most highly expressed AC isoform in the inner medulla, inversely …