The tRNA‐like small noncoding RNA masc RNA promotes global protein translation
X Lu, J Huang, S Wu, Q Zheng, P Liu, H Feng, X Su… - EMBO …, 2020 - embopress.org
EMBO reports, 2020•embopress.org
Abstract masc RNA is a small cytoplasmic RNA derived from the lnc RNA MALAT 1. After
being processed by the tRNA processing enzymes RN ase P and RN ase Z, masc RNA
undergoes CCA addition like tRNA s and folds into a tRNA‐like cloverleaf structure. While
MALAT 1 functions in multiple cellular processes, the role of masc RNA was largely
unknown. Here, we show that masc RNA binds directly to the multi‐tRNA synthetase
complex (MSC) component glutaminyl‐tRNA synthetase (QARS). masc RNA promotes …
being processed by the tRNA processing enzymes RN ase P and RN ase Z, masc RNA
undergoes CCA addition like tRNA s and folds into a tRNA‐like cloverleaf structure. While
MALAT 1 functions in multiple cellular processes, the role of masc RNA was largely
unknown. Here, we show that masc RNA binds directly to the multi‐tRNA synthetase
complex (MSC) component glutaminyl‐tRNA synthetase (QARS). masc RNA promotes …
Abstract
mascRNA is a small cytoplasmic RNA derived from the lncRNA MALAT1. After being processed by the tRNA processing enzymes RNase P and RNase Z, mascRNA undergoes CCA addition like tRNAs and folds into a tRNA‐like cloverleaf structure. While MALAT1 functions in multiple cellular processes, the role of mascRNA was largely unknown. Here, we show that mascRNA binds directly to the multi‐tRNA synthetase complex (MSC) component glutaminyl‐tRNA synthetase (QARS). mascRNA promotes global protein translation and cell proliferation by positively regulating QARS protein levels. Our results uncover a role of mascRNA that is independent of MALAT1, but could be part of the molecular mechanism of MALAT1's function in cancer, and provide a paradigm for understanding tRNA‐like structures in mammalian cells.
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