[HTML][HTML] In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials
N Tappenbeck, HM Schröder, E Niebergall-Roth… - Cytotherapy, 2019 - Elsevier
Background aims Human dermal ABCB5-expressing mesenchymal stromal cells (ABCB5+
MSCs) represent a promising candidate for stem cell–based therapy of various currently
uncurable diseases in several fields of regenerative medicine. We have developed and
validated a method to isolate, from human skin samples, and expand ABCB5+ MSCs that
meet the guideline criteria of the International Society for Cellular Therapy. We are able to
process these cells into a Good Manufacturing Practice–conforming, MSC-based advanced …
MSCs) represent a promising candidate for stem cell–based therapy of various currently
uncurable diseases in several fields of regenerative medicine. We have developed and
validated a method to isolate, from human skin samples, and expand ABCB5+ MSCs that
meet the guideline criteria of the International Society for Cellular Therapy. We are able to
process these cells into a Good Manufacturing Practice–conforming, MSC-based advanced …