[HTML][HTML] Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter

NY Frank, SS Pendse, PH Lapchak… - Journal of Biological …, 2003 - ASBMB
Cell fusion involving progenitor cells is a newly recognized phenomenon thought to
contribute to tissue differentiation. The molecular mechanisms governing cell fusion are
unknown. P-glycoprotein and related ATP-binding cassette transporters are expressed by
progenitor cells, but their physiological role in these cell types has not been defined. Here,
we have cloned ABCB5, a rhodamine efflux transporter and novel member of the human P-
glycoprotein family, which marks CD133-expressing progenitor cells among human …