[HTML][HTML] Development of the nonobese diabetic mouse and contribution of animal models for understanding type 1 diabetes
Y Mullen - Pancreas, 2017 - journals.lww.com
Y Mullen
Pancreas, 2017•journals.lww.comIn 1974, the discovery of a mouse and a rat that spontaneously developed hyperglycemia
led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse
and Bio-Breeding rat. These models have contributed to our understanding of autoimmune
diabetes, provided tools to dissect autoimmune islet damage, and facilitated development of
early detection, prevention, and treatment of type 1 diabetes. The genetic characterization,
monoclonal antibodies, and congenic strains have made NOD mice especially useful.
led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse
and Bio-Breeding rat. These models have contributed to our understanding of autoimmune
diabetes, provided tools to dissect autoimmune islet damage, and facilitated development of
early detection, prevention, and treatment of type 1 diabetes. The genetic characterization,
monoclonal antibodies, and congenic strains have made NOD mice especially useful.
Abstract
In 1974, the discovery of a mouse and a rat that spontaneously developed hyperglycemia led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse and Bio-Breeding rat. These models have contributed to our understanding of autoimmune diabetes, provided tools to dissect autoimmune islet damage, and facilitated development of early detection, prevention, and treatment of type 1 diabetes. The genetic characterization, monoclonal antibodies, and congenic strains have made NOD mice especially useful.
Lippincott Williams & Wilkins