[HTML][HTML] Btk inhibition treats TLR7/IFN driven murine lupus
AT Bender, A Pereira, K Fu, E Samy, Y Wu… - Clinical …, 2016 - Elsevier
Bruton's tyrosine kinase (Btk) is expressed in a variety of immune cells and previous work
has demonstrated that blocking Btk is a promising strategy for treating autoimmune
diseases. Herein, we utilized a tool Btk inhibitor, M7583, to determine the therapeutic
efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I
interferon. In BXSB-Yaa lupus mice, Btk inhibition reduced autoantibodies, nephritis, and
mortality. In the pristane-induced DBA/1 lupus model, Btk inhibition suppressed arthritis, but …
has demonstrated that blocking Btk is a promising strategy for treating autoimmune
diseases. Herein, we utilized a tool Btk inhibitor, M7583, to determine the therapeutic
efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I
interferon. In BXSB-Yaa lupus mice, Btk inhibition reduced autoantibodies, nephritis, and
mortality. In the pristane-induced DBA/1 lupus model, Btk inhibition suppressed arthritis, but …