Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
JV Bonventre - Journal of the American Society of Nephrology, 2003 - journals.lww.com
In contrast to the heart or brain, the kidney can completely recover from an ischemic or toxic
insult that results in cell death. During recovery from ischemia/reperfusion injury, surviving
tubular epithelial cells dedifferentiate and proliferate, eventually replacing the irreversibly
injured tubular epithelial cells and restoring tubular integrity. Repair of the kidney parallels
kidney organogenesis in the high rate of DNA synthesis and apoptosis and in patterns of
gene expression. As has been shown by proliferating cell nuclear antigen and 5-bromo 2 …
insult that results in cell death. During recovery from ischemia/reperfusion injury, surviving
tubular epithelial cells dedifferentiate and proliferate, eventually replacing the irreversibly
injured tubular epithelial cells and restoring tubular integrity. Repair of the kidney parallels
kidney organogenesis in the high rate of DNA synthesis and apoptosis and in patterns of
gene expression. As has been shown by proliferating cell nuclear antigen and 5-bromo 2 …