We have recently shown that IgG1 directed against antigens thought to be involved in the
pathogenesis of rheumatoid arthritis harbor different glycan moieties on their Fc-tail, as
compared with total sera IgG1. Given the crucial roles of Fc-linked N-glycans for the structure
and biological activity of IgG, Fc-glycosylation of antibodies is receiving considerable
interest. However, so far little is known about the signals and factors that could influence the
composition of these carbohydrate structures on secreted IgG produced by B lymphocytes …