Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic …

TK Loke, KH Mallett, J Ratoff, BJ O'Connor… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Overexpression of the transcriptional regulatory factor activator protein 1
might contribute to T-cell glucocorticoid (GC) refractoriness in GC-resistant asthma.
OBJECTIVE: We sought to address the hypothesis that clinically GC-resistant asthma is
accompanied by failure of systemic GCs to inhibit phosphorylation of c-jun and c-jun N-
terminal kinase (JNK) in bronchial mucosal cells. METHODS: We performed enumeration of
total (CD45+) leukocytes and cells expressing c-fos and total and phosphorylated c-jun and …