Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype

M Camiolo, M Gauthier, N Kaminski, A Ray… - Journal of Allergy and …, 2020 - Elsevier
Background More than 300 million people carry a diagnosis of asthma, with data to suggest
that they are at a higher risk for infection or adverse outcomes from severe acute respiratory
syndrome coronavirus 2. Asthma is remarkably heterogeneous, and it is currently unclear
how patient-intrinsic factors may relate to coronavirus disease 2019. Objective We sought to
identify and characterize subsets of patients with asthma at increased risk for severe acute
respiratory syndrome coronavirus 2 infection. Methods Participants from 2 large asthma …