[HTML][HTML] Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-
6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS)
in asthmatic patients is unclear. Objective We sought to explore the association between
epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic
patients. Methods An IL-6TS gene signature obtained from air-liquid interface cultures of
human bronchial epithelial cells stimulated with IL-6 and sIL-6R was used to stratify lung …
6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS)
in asthmatic patients is unclear. Objective We sought to explore the association between
epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic
patients. Methods An IL-6TS gene signature obtained from air-liquid interface cultures of
human bronchial epithelial cells stimulated with IL-6 and sIL-6R was used to stratify lung …
