Essentials• To reliably study the respective roles of blood and endothelial cells in
hemostasis, mouse models with a strong and specific endothelial expression of the Cre
recombinase are needed.• Using mT/mG reporter mice and conditional JAK2 V617F/WT
mice, we compared Pdgfb‐iCreERT2 and Cdh5 (PAC)‐CreERT2 with well‐characterized
Tie2‐Cre mice.• Comparison of recombination efficiency and specificity towards blood
lineage reveals major differences between endothelial transgenic mice.• Cre‐mediated …