REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) …
E Frangou, A Chrysanthopoulou, A Mitsios… - Annals of the Rheumatic …, 2019 - Elsevier
Objectives The release of neutrophil extracellular traps (NETs) represents a novel neutrophil
effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the
molecular mechanism underlying NET release and how NETs mediate end-organ injury in
SLE remain elusive. Methods NET formation and NET-related proteins were assessed in the
peripheral blood and biopsies from discoid lupus and proliferative nephritis, using
immunofluorescence, immunoblotting, quantitative PCR and ELISA. Autophagy was …
effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the
molecular mechanism underlying NET release and how NETs mediate end-organ injury in
SLE remain elusive. Methods NET formation and NET-related proteins were assessed in the
peripheral blood and biopsies from discoid lupus and proliferative nephritis, using
immunofluorescence, immunoblotting, quantitative PCR and ELISA. Autophagy was …
