Development of newborn and infant vaccines
G Sanchez-Schmitz, O Levy - Science translational medicine, 2011 - science.org
G Sanchez-Schmitz, O Levy
Science translational medicine, 2011•science.orgVaccines for early-life immunization are a crucial biomedical intervention to reduce global
morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and
inconsistent. Immune responses of human newborns and infants are distinct and cannot be
predicted from those of human adults or animal models. Therefore, understanding and
modeling age-specific human immune responses will be vital to the rational design and
development of safe and effective vaccines for newborns and infants.
morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and
inconsistent. Immune responses of human newborns and infants are distinct and cannot be
predicted from those of human adults or animal models. Therefore, understanding and
modeling age-specific human immune responses will be vital to the rational design and
development of safe and effective vaccines for newborns and infants.
Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.
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