Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in infants and toddlers

SH Yeh, A Gurtman, DC Hurley, SL Block… - …, 2010 - publications.aap.org
BACKGROUND: 7-Valent pneumococcal conjugate vaccine (PCV7 [Prevnar, Wyeth
Pharmaceuticals Inc, Philadelphia, PA], serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F) is
effective in preventing vaccine-serotype pneumococcal disease. 13-Valent pneumococcal
conjugate vaccine (PCV13)(PCV7 serotypes plus 1, 3, 5, 6A, 7F, and 19A) was designed to
provide broader pneumococcal disease coverage. We evaluated the immunogenicity and
safety of PCV13 compared with PCV7. METHODS: Infants received PCV13 or PCV7 at ages …