The role of IL-15 in gastrointestinal diseases: a bridge between innate and adaptive immune response
D Pagliari, R Cianci, S Frosali, R Landolfi… - Cytokine & growth factor …, 2013 - Elsevier
IL-15 is a member of the IL-2 family of cytokines whose signaling pathways are a bridge
between innate and adaptive immune response. IL-15 is part of the intestinal mucosal
barrier, and functions to modulate gut homeostasis. IL-15 has pivotal roles in the control of
development, proliferation and survival of both innate and adaptive immune cells. IL-15
becomes up-regulated in the inflamed tissue of intestinal inflammatory disease, such as IBD,
Celiac Disease and related complications. Indeed, several studies have reported that IL-15 …
between innate and adaptive immune response. IL-15 is part of the intestinal mucosal
barrier, and functions to modulate gut homeostasis. IL-15 has pivotal roles in the control of
development, proliferation and survival of both innate and adaptive immune cells. IL-15
becomes up-regulated in the inflamed tissue of intestinal inflammatory disease, such as IBD,
Celiac Disease and related complications. Indeed, several studies have reported that IL-15 …