[HTML][HTML] Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33

C Michaudel, C Mackowiak, I Maillet… - Journal of Allergy and …, 2018 - Elsevier
Background IL-33 plays a critical role in regulation of tissue homeostasis, injury, and repair.
Whether IL-33 regulates neutrophil recruitment and functions independently of airways
hyperresponsiveness (AHR) in the setting of ozone-induced lung injury and inflammation is
unclear. Objective We sought to examine the role of the IL-33/ST2 axis in lung inflammation
on acute ozone exposure in mice. Methods ST2-and Il33–deficient, IL-33 citrine reporter,
and C57BL/6 (wild-type) mice underwent a single ozone exposure (1 ppm for 1 hour) in all …