[HTML][HTML] Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis
M Picher, LH Burch, RC Boucher - Journal of Biological Chemistry, 2004 - ASBMB
Extracellular nucleotides are among the most potent mediators of mucociliary clearance
(MCC) in human lungs. However, clinical trials revealed that aerosolized nucleotides
provide only a transient improvement of MCC to patients diagnosed with cystic fibrosis (CF).
In this study, we identified the mechanism that eliminates extracellular nucleotides from
human airways. Polarized primary cultures of human bronchial epithelial cells were
impermeable to extracellular nucleotides but rapidly dephosphorylated ATP into ADP, AMP …
(MCC) in human lungs. However, clinical trials revealed that aerosolized nucleotides
provide only a transient improvement of MCC to patients diagnosed with cystic fibrosis (CF).
In this study, we identified the mechanism that eliminates extracellular nucleotides from
human airways. Polarized primary cultures of human bronchial epithelial cells were
impermeable to extracellular nucleotides but rapidly dephosphorylated ATP into ADP, AMP …