Interferonγ/IL10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosis

B Jamil, F Shahid, Z Hasan, N Nasir, T Razzaki… - Tuberculosis, 2007 - Elsevier
Several cytokines (IFNγ, TNFα, IL10 and IL6) show an association with either disease
localization or dissemination in tuberculosis. There are also reports of involvement of extra-
pulmonary sites in tuberculosis with differential clinical severity. However, no comparative
study of biomarkers across the disease severity spectrum is available. This was the purpose
of the current study. Cytokines (IFNγ, TNFα, IL10 and IL6) secreted in response to a panel of
stimulants (PHA, LPS or mycobacterial antigens) in whole blood were determined in eighty …