[HTML][HTML] Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
JJ Senn, PJ Klover, IA Nowak, TA Zimmers… - Journal of Biological …, 2003 - ASBMB
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in insulin
resistance during infection, cachexia, and obesity. We recently demonstrated that IL-6
inhibits insulin signaling in hepatocytes (Senn, JJ, Klover, PJ, Nowak, IA, and Mooney, RA
(2002) Diabetes51, 3391–3399). Members of the suppressors of cytokine signaling (SOCS)
family associate with the insulin receptor (IR), and their ectopic expression inhibits IR
signaling. Since several SOCS proteins are induced by IL-6, a working hypothesis is that IL …
resistance during infection, cachexia, and obesity. We recently demonstrated that IL-6
inhibits insulin signaling in hepatocytes (Senn, JJ, Klover, PJ, Nowak, IA, and Mooney, RA
(2002) Diabetes51, 3391–3399). Members of the suppressors of cytokine signaling (SOCS)
family associate with the insulin receptor (IR), and their ectopic expression inhibits IR
signaling. Since several SOCS proteins are induced by IL-6, a working hypothesis is that IL …