[HTML][HTML] Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
JH Kim, JE Kim, HY Liu, W Cao, J Chen - Journal of Biological Chemistry, 2008 - ASBMB
The proinflammatory cytokine interleukin (IL)-6 has been proposed to be one of the
mediators that link obesity-derived chronic inflammation with insulin resistance. Signaling
through the mammalian target of rapamycin (mTOR) has been found to impact insulin
sensitivity under various pathological conditions, through serine phosphorylation and
inhibition of insulin receptor substrate by the downstream effector of mTOR, ribosomal S6
kinase 1 (S6K1). However, an involvement of mTOR in IL-6-induced insulin resistance has …
mediators that link obesity-derived chronic inflammation with insulin resistance. Signaling
through the mammalian target of rapamycin (mTOR) has been found to impact insulin
sensitivity under various pathological conditions, through serine phosphorylation and
inhibition of insulin receptor substrate by the downstream effector of mTOR, ribosomal S6
kinase 1 (S6K1). However, an involvement of mTOR in IL-6-induced insulin resistance has …