[HTML][HTML] Human IL-6RhiTIGIT− CD4+ CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile
RC Ferreira, DB Rainbow, AR García, ML Pekalski… - Clinical …, 2017 - Elsevier
To date many clinical studies aim to increase the number and/or fitness of CD4+ CD127 low
CD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of
treating autoimmune disease. Here, we sought to define the phenotype and function of
Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population
of CD4+ CD127 low CD25+ TIGIT− T cells distinguished by their elevated IL-6R expression
that lacked expression of HELIOS, showed higher CTLA-4 expression, and displayed …
CD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of
treating autoimmune disease. Here, we sought to define the phenotype and function of
Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population
of CD4+ CD127 low CD25+ TIGIT− T cells distinguished by their elevated IL-6R expression
that lacked expression of HELIOS, showed higher CTLA-4 expression, and displayed …