IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants
C Ranasinghe, S Trivedi, DK Wijesundara… - Cytokine & growth factor …, 2014 - Elsevier
The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated
immunity have received considerable scrutiny, however, mechanisms by which these
cytokines influence the cellular interactions involved in negatively modulating the
development of effective Th1 immunity are poorly characterized. In this article we discuss the
recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic
inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and …
immunity have received considerable scrutiny, however, mechanisms by which these
cytokines influence the cellular interactions involved in negatively modulating the
development of effective Th1 immunity are poorly characterized. In this article we discuss the
recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic
inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and …