Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells

H Kimura, D Francisco, M Conway, FD Martinez… - Journal of Allergy and …, 2020 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
dramatically changed our world, country, communities, and families. There is controversy
regarding risk factors for severe COVID-19 disease. It has been suggested that asthma and
allergy are not highly represented as comorbid conditions associated with COVID-19.
Objective Our aim was to extend our work in IL-13 biology to determine whether airway
epithelial cell expression of 2 key mediators critical for SARS-CoV-2 infection, namely …