Exposure to fungi can result in a wide range of comorbidities depending on the immune
status of the host. Chronic exposure and reactivity to fungi such as Aspergillus fumigatus can
result in conditions such as severe asthma with fungal sensitization (SAFS) or allergic
bronchopulmonary aspergillosis (ABPA). However, the pathophysiology of SAFS and ABPA
is not well understood. Here, we report that the chitinase-like protein YKL-40 is elevated in
lung lavage fluid from humans with asthma that are sensitized to fungi. Initial studies …

Lung Diseases in Reverse Translation: Bedside to the Bench: Chitinase 3-like-1 protects
airway function despite promoting type 2 inflammation during fungal-associated allergic airway
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