ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway
R Ye, Z Liu - Experimental and molecular pathology, 2020 - Elsevier
This study aimed to investigate the protective effect of angiotensin converting enzyme 2
(ACE2) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). After generating ALI
mouse models by injecting LPS, the levels of ACE2, inflammatory factors, and downstream
proteins of the LPS-TLR4 pathway were analyzed. LPS-challenged BEAS-2B cells were
established in vitro. Next, a eukaryotic expression vector, pm-ACE2, was constructed and
validated. Challenged cells were transfected with pm-ACE2 containing enhanced green …
(ACE2) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). After generating ALI
mouse models by injecting LPS, the levels of ACE2, inflammatory factors, and downstream
proteins of the LPS-TLR4 pathway were analyzed. LPS-challenged BEAS-2B cells were
established in vitro. Next, a eukaryotic expression vector, pm-ACE2, was constructed and
validated. Challenged cells were transfected with pm-ACE2 containing enhanced green …