YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis
C Østergaard, JS Johansen, T Benfield… - Clinical and Vaccine …, 2002 - Am Soc Microbiol
ABSTRACT YKL-40, a member of the family 18 glycosyl hydrolases, is secreted by activated
neutrophils and macrophages. It is a growth factor for connective tissue cells and a potent
migration factor for endothelial cells and may function in inflammation and tissue
remodeling. YKL-40 was determined in 134 cerebrospinal fluid (CSF) samples taken on
admission from patients suspected of having meningitis (48 with purulent meningitis, 49 with
lymphocytic meningitis, 5 with encephalitis, and 32 without evidence of meningitis). YKL-40 …
neutrophils and macrophages. It is a growth factor for connective tissue cells and a potent
migration factor for endothelial cells and may function in inflammation and tissue
remodeling. YKL-40 was determined in 134 cerebrospinal fluid (CSF) samples taken on
admission from patients suspected of having meningitis (48 with purulent meningitis, 49 with
lymphocytic meningitis, 5 with encephalitis, and 32 without evidence of meningitis). YKL-40 …
Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and is associated with fatal outcome
C Østergaard, T Benfield, JD Lundgren… - … journal of infectious …, 2004 - Taylor & Francis
The urokinase-type plasminogen activator system has been suggested to play a
pathophysiological role in brain damage. The aim of this study was to evaluate CSF levels of
suPAR in 183 patients clinically suspected of having meningitis on admission. Of these, 54
patients were found to have purulent meningitis, 63 had lymphocytic meningitis, 12 had
encephalitis, and 54 patients were suspected of, but had no evidence of, meningitis. There
was a significant difference in suPAR levels among patient groups (Kruskal Wallis test, p< …
pathophysiological role in brain damage. The aim of this study was to evaluate CSF levels of
suPAR in 183 patients clinically suspected of having meningitis on admission. Of these, 54
patients were found to have purulent meningitis, 63 had lymphocytic meningitis, 12 had
encephalitis, and 54 patients were suspected of, but had no evidence of, meningitis. There
was a significant difference in suPAR levels among patient groups (Kruskal Wallis test, p< …