The differentiation of naive T cells into distinct subsets of effector T cells is critical for effective
immunity against a wide variety of infectious agents in the environment. Activation of innate
immune responses by Candida species through pattern-recognition receptors directs the
subsequent development of naive T cells into TH17 cells, which are essential for effective
mucosal immunity against fungi. Thorough analyses of cohorts of patients with unusual
susceptibility to chronic mucocutaneous candidiasis resulting from TH17 deficiency have …