Counterregulation between thymic stromal lymphopoietin–and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects

J Li, JM Leyva-Castillo, P Hener, A Eisenmann… - Journal of Allergy and …, 2016 - Elsevier
Background Epidermal barrier dysfunction has been recognized as a critical factor in the
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis
(AD) and AD-like congenital disorders, including peeling skin syndrome type B. However,
inflammatory responses developed in barrier-defective skin, as well as the underlying
mechanisms, remained incompletely understood. Objective We aimed to decipher
inflammatory axes and the cytokine network in mouse skin on breakdown of epidermal …