IL-1 receptor antagonist treatment aggravates staphylococcal septic arthritis and sepsis in mice
A Ali, M Na, MND Svensson, M Magnusson, A Welin… - PloS one, 2015 - journals.plos.org
A Ali, M Na, MND Svensson, M Magnusson, A Welin, JC Schwarze, M Mohammad…
PloS one, 2015•journals.plos.orgBackground Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against
autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and
associated organ injury. However, patients receiving IL-1Ra might be at increased risk of
acquiring serious infections. Aims To study whether IL-1Ra treatment deteriorates
Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice. Method NMRI mice
were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S …
autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and
associated organ injury. However, patients receiving IL-1Ra might be at increased risk of
acquiring serious infections. Aims To study whether IL-1Ra treatment deteriorates
Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice. Method NMRI mice
were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S …
Background
Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.
Aims
To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice.
Method
NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups.
Results
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls.
Conclusion
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.
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