Genetic models for CNS inflammation

T Owens, H Wekerle, J Antel - Nature medicine, 2001 - nature.com
T Owens, H Wekerle, J Antel
Nature medicine, 2001nature.com
The use of transgenic technology to over-express or prevent expression of genes encoding
molecules related to inflammation has allowed direct examination of their role in
experimental disease. This article reviews transgenic and knockout models of CNS
demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as
well as conditions in which an inflammatory response makes a secondary contribution to
tissue injury or repair, such as neurodegeneration, ischemia and trauma.
Abstract
The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as conditions in which an inflammatory response makes a secondary contribution to tissue injury or repair, such as neurodegeneration, ischemia and trauma.
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