[HTML][HTML] Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck
S Xi, Q Zhang, KF Dyer, EC Lerner, TE Smithgall… - Journal of Biological …, 2003 - ASBMB
Signal transducer and activator of transcription (STAT) proteins are constitutively activated in
many malignancies, including squamous cell carcinoma of the head and neck (SCCHN).
Previously, we reported that phosphorylation of the epidermal growth factor receptor (EGFR)
is linked to activation of STATs 3 and 5 in SCCHN cells. The present study was undertaken
to determine the role of Src family kinases in STAT activation and SCCHN growth. The Src
family kinases c-Src, c-Yes, Fyn, and Lyn were expressed and activated by transforming …
many malignancies, including squamous cell carcinoma of the head and neck (SCCHN).
Previously, we reported that phosphorylation of the epidermal growth factor receptor (EGFR)
is linked to activation of STATs 3 and 5 in SCCHN cells. The present study was undertaken
to determine the role of Src family kinases in STAT activation and SCCHN growth. The Src
family kinases c-Src, c-Yes, Fyn, and Lyn were expressed and activated by transforming …