Dose-response association of CD8+ tumor-infiltrating lymphocytes and survival time in high-grade serous ovarian cancer
EL Goode, MS Block, KR Kalli, RA Vierkant… - JAMA …, 2017 - jamanetwork.com
Importance Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune
control of epithelial ovarian cancer; however, little is known about prognostic patterns of
CD8+ TILs by histotype and in relation to other clinical factors. Objective To define the
prognostic role of CD8+ TILs in epithelial ovarian cancer. Design, Setting, and Participants
This was a multicenter observational, prospective survival cohort study of the Ovarian Tumor
Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade …
control of epithelial ovarian cancer; however, little is known about prognostic patterns of
CD8+ TILs by histotype and in relation to other clinical factors. Objective To define the
prognostic role of CD8+ TILs in epithelial ovarian cancer. Design, Setting, and Participants
This was a multicenter observational, prospective survival cohort study of the Ovarian Tumor
Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade …