Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on …
ES Roberts, EME Burudi, C Flynn, LJ Madden… - Journal of …, 2004 - Elsevier
The virus/host interactions during the acute phase of human immunodeficiency virus (HIV)
infection help determine the course of disease. During this time period, virus enters the
brain. Here, we report clusters of genes whose transcripts are significantly upregulated in
the frontal lobe of the brain during acute simian immunodeficiency virus (SIV) infection of
rhesus monkeys. Many of these genes are involved in interferon (IFN) and/or interleukin (IL)-
6 pathways. Although neither IFNα nor IFNγ are elevated in the brain, IL6 is increased. Both …
infection help determine the course of disease. During this time period, virus enters the
brain. Here, we report clusters of genes whose transcripts are significantly upregulated in
the frontal lobe of the brain during acute simian immunodeficiency virus (SIV) infection of
rhesus monkeys. Many of these genes are involved in interferon (IFN) and/or interleukin (IL)-
6 pathways. Although neither IFNα nor IFNγ are elevated in the brain, IL6 is increased. Both …