What is the predictive value of animal models for vaccine efficacy in humans? Rigorous simian immunodeficiency virus vaccine trials can be instructive
MA Martins, DI Watkins - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
MA Martins, DI Watkins
Cold Spring Harbor perspectives in biology, 2018•cshperspectives.cshlp.orgSimian immunodeficiency virus (SIV) challenge of rhesus macaques provides an invaluable
tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any
animal model of human disease, it is crucial to understand the advantages and limitations of
this system to maximize the translational value of SIV vaccine studies. Here, we discuss the
importance of assessing the efficacy of vaccine prototypes using stringent SIV challenge
regimens that mimic HIV-1 transmission and pathogenesis. We also review some of the …
tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any
animal model of human disease, it is crucial to understand the advantages and limitations of
this system to maximize the translational value of SIV vaccine studies. Here, we discuss the
importance of assessing the efficacy of vaccine prototypes using stringent SIV challenge
regimens that mimic HIV-1 transmission and pathogenesis. We also review some of the …
Simian immunodeficiency virus (SIV) challenge of rhesus macaques provides an invaluable tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any animal model of human disease, it is crucial to understand the advantages and limitations of this system to maximize the translational value of SIV vaccine studies. Here, we discuss the importance of assessing the efficacy of vaccine prototypes using stringent SIV challenge regimens that mimic HIV-1 transmission and pathogenesis. We also review some of the cautionary tales of HIV-1 vaccine research because they provide general lessons for the preclinical assessment of vaccine candidates.
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