Structure and interactions of the human programmed cell death 1 receptor
PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of
immune responses and a promising therapeutic target. The structure and interactions of
human PD-1 are, however, incompletely characterized. We present the solution nuclear
magnetic resonance (NMR)-based structure of the human PD-1 extracellular region and
detailed analyses of its interactions with its ligands, PD-L1 and PD-L2. PD-1 has typical
immunoglobulin superfamily topology but differs at the edge of the GFCC′ sheet, which is …
immune responses and a promising therapeutic target. The structure and interactions of
human PD-1 are, however, incompletely characterized. We present the solution nuclear
magnetic resonance (NMR)-based structure of the human PD-1 extracellular region and
detailed analyses of its interactions with its ligands, PD-L1 and PD-L2. PD-1 has typical
immunoglobulin superfamily topology but differs at the edge of the GFCC′ sheet, which is …