Strategies to guide the antibody affinity maturation process

NA Doria-Rose, MG Joyce - Current opinion in virology, 2015 - Elsevier
Highlights•Broadly neutralizing HIV-1 and influenza antibodies possess significant levels of
affinity maturation.•Choice of initial immunogens may be critical to select naïve B cells that
can mature appropriately.•Viral diversity leads to development of broadly neutralizing
antibodies.•HIV-1 and influenza immunogen design breakthroughs.•Antibody-virus co-
evolution studies in HIV-1 and influenza infections suggest immunization
strategies.Antibodies with protective activity are critical for vaccine efficacy. Affinity …